A powerful network of technologies driven by smart processes.
Tailor-made services for hit identification, hit confirmation, hit characterization, and support of hit-to-lead programs. We cover target validation, assay development, liquid handling, screening, SAR and MedChem support, critical data processing and analysis, as well as comprehensive and clear reporting of results.
Also check small molecules for solubility and precipitation parameters to assist in ligand selection and drive of lead molecule generation.
Fit to the needs of fragment-based drug discovery, we provide specialized fragment libraries as well as the right tools for screening them. In addition, we cover the required experimental parts for fragment growth, MedChem cycles, SAR by catalogue and fragment-to-lead programs.
Specialized binding and screening assays and services for identification, characterization, and optimization of covalent drugs.
Also check covalent compounds for solubility and precipitation parameters to assist in ligand selection and drive of lead molecule generation.
We understand that these special chemical molecules require specialized assay formats. We provide not only binary binding analysis of PROTACs and molecular glues to their two targets, but also direct measurement of their intended function, bringing together two normally not associated targets. We can do this by direct analysis of ternary complex formation with full kinetic, affinity, and avidity information.
Also check molecules for solubility and precipitation parameters to assist in ligand selection and drive of lead molecule generation.
We cover binding kinetics, off-rate ranking, epitope-binning, test of avidity effects, as well as binding analysis of antibodies on live cells. The latter is especially useful for challenging targets that cannot be purified and have to be tested in their cellular context.
We ensure the developability of your antibodies through a battery of advanced techniques, including nanoDSF, DLS, SEC-MALS, HIC, and IEX. This comprehensive approach provides invaluable insights into key parameters such as thermal and colloidal stability, self-interaction, hydrophobicity, and chemical stability. Furthermore, our formulation studies, driven by statistically sound design of experiments (DoE), proactively address potential risk factors, paving the way for successful development.
2bind’s comprehensive portfolio delivers in-depth characterization of your antibodies and bispecifics, providing critical insights into binding interactions with target proteins and cells, along with meticulous assessments of conformational, colloidal, and chemical stability. We tailor these studies to meet your specific needs, whether you require a comprehensive analysis or targeted answers to particular scientific questions.
Characterize and optimize! Set the basis for successful development campaigns with detailed target characterization in terms of stability, purity, homogeneity, hydrophobicity, charge state, and more. Optimize these parameters with high-throughput capable, statistically driven (DoE) assays.
Besides gold-standards like ITC, BLI, TRIC, or Wyatt DLS, we continuously integrate cutting-edge tools like GCI (Wave), RT-IC (heliXcyto), or Spectral Shift. Developer certifications ensure that we provide these technologies to the highest possible quality standards.
From Biotech, Pharma, and Academia
As scientists we understand that successful research requires a clear but also flexible approach. Our quotations, project and reports reflect this need with a fine-grained milestone architecture with multiple stop criteria and exit options.
