Work with the Experts in Biophysics

Our mission is to accelerate your research by developing and applying high-end, scalable assays for

Drug Discovery

Antibody Development

Aptamer Research

Protein Biophysics

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Main Services

Drug Discovery

  • Hit Identification
  • Hit Validation
  • Hit Characterization
  • Protein-targeted
  • RNA-targeted

Antibody Development

  • Folding and stability
  • Pre-formulation
  • Antigen-binding affinity
  • Antigen-binding kinetics

Aptamer Research

  • DNA, RNA, synthetic aptamers
  • Aptamer validation
  • Affinity and kinetic characterization

Protein Biophysics

  • Protein-protein interactions (PPIs)
  • PPI-inhibitor screening
  • Enzyme stabilization
  • Folding and stability
  • Pre-formulation

Additional Services

Protein and compound sourcing

Assay development consulting

Data analysis and scientific consulting

Assay transfer and setup

Chromatin pro-duction + assembly

Our Mindset – why you should work with us

Milestone-based projects

Milestones and exit-options give you the full control over your projects.

Clear cost-structure

All costs are known prior to project start. Cancelled milestones are not charged.

Fast turn-around times

The structured project pipeline ensures turn-around times of few working days even for complex screening projects.

Long-standing expertise

2bind is the first CRO certified by NanoTemper for MST and nanoDSF.

Personal project manager

All customer projects are handled by highly skilled, PhD-level biochemists and biophysicists.

Customers from Pharma, Biotech, and Academia

Completed contract research projects

Years of experience with MST and nanoDSF

Protein, DNA, RNA targets analyzed

State-of-the-art Biophysics

Our state-of-the-art portfolio of biophysical technologies enables us to provide you with a complete and comprehensive picture of your specific question: From affinity and stability to kinetics and thermodynamics.

KD | EC50 | Tm | ΔTm | Tagg | ΔTagg | kon | koff | n | ΔH | ΔG | ΔS

MST

  • Steady-state affinity
  • Ligand binding
  • Screening
  • Proteins, DNA, RNA
  • Bioliquids

nanoDSF

  • Protein stability
  • Protein unfolding
  • Protein aggregation
  • Ligand binding
  • Screening
  • Bioliquids

BLI

  • Kinetics
  • Ligand binding
  • Antibody development
  • Off-rate ranking
  • Bioliquids

ITC

  • Thermodynamics
  • Stoichiometry
  • Ligand binding

Clients & Partners

We are impressed with the rapid turnaround time and excellent service, as well the high quality data generated at 2bind.

Brian Hamman, Director of Biophysics  Arvinas, Inc.
Brian Hamman, Director of Biophysics

The [2bind] assay development was well-planned, careful and methodical. Progress reports were frequent, very clear and meticulously prepared. Their science and professionalism are impeccable – working with 2bind is like having expert biophysicists in the lab next door!

Chris Lepre, PhD, Biochemistry, Biophysics and Structural Biology  Relay Therapeutics, Inc.
Chris Lepre, PhD, Biochemistry, Biophysics and Structural Biology

The MST experts at 2bind were successfull in setting up various binding assays, stoichiometry assays, and competition assays and helped us to drive our science. We are very satisfied with the low sample consumption and the fast turnaround time.

Mads Nøregaard-Madsen, Chief Innovation & Information Officer  Nuevolution
Mads Nøregaard-Madsen, Chief Innovation & Information Officer

During several years we have had excellent experience working with 2bind. They have always provided us with the highest-quality services. Quick responsiveness of 2bind’s team has helped us to accelerate projects.

Dmitry Shishov  Gero
Dmitry Shishov

We have enjoyed the quality of service of 2bind coupled to a great flexibility. 2bind’s technology allowed us to quickly assess target validation with dozens of proteins and helped us advance quickly on the subject.

Philippe Verwaerde, President and CSO  AlzProtect
Philippe Verwaerde, President and CSO

We use nanoDSF analyses performed by the experienced team of 2bind in order to gain insights into specific protein parameters. Beside the fast realization and the low sample consumption, we are impressed by the great consistency of both methods.

Martin Griessl, CEO  Lysando
Martin Griessl, CEO

We have been using NanoTemper devices for over eight years and have established a close and very productive relationship together. 2bind has the highest density of NanoTemper devices in one lab world-wide.

Assay.Works is our go-to partner for all biochemical and cell-based assay development and screening requirements. We partner also in the area of ligand compound and bioactive tool compound libraries.

Media and Ressources

We are sure there is a service for your exact needs!
Have a look at the 2bind Application Notes and peer-reviewed publications to see what we can do!

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