Work with the Experts in Biophysics

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Our mission is to accelerate your research by developing and applying high-end, scalable assays for

Drug Discovery

Antibody Development

Aptamer Research

Protein Biophysics

Main Services

Drug Discovery

Hit Identification
Hit Validation
Hit Characterization
Protein-targeted
RNA-targeted

Antibody Development

Folding and stability
Pre-formulation
Antigen-binding affinity
Antigen-binding kinetics

Aptamer Research

DNA, RNA, synthetic aptamers
Aptamer validation
Affinity and kinetic characterization

Protein Biophysics

Protein-protein interactions (PPIs)
PPI-inhibitor screening
Enzyme stabilization
Folding and stability
Pre-formulation

Additional Services

Protein and compound sourcing

Assay development consulting

Data analysis and scientific consulting

Assay transfer and setup

Chromatin pro-duction + assembly

Our Mindset – why you should work with us

Milestone-based projects

Milestones and exit-options give you the full control over your projects.

Clear cost-structure

All costs are known prior to project start. Cancelled milestones are not charged.

Fast turn-around times

The structured project pipeline ensures turn-around times of few working days even for complex screening projects.

Long-standing expertise

2bind is the first CRO certified by NanoTemper for MST and nanoDSF.

Personal project manager

All customer projects are handled by highly skilled, PhD-level biochemists and biophysicists.

Customers from Pharma, Biotech, and Academia

Completed contract research projects

Years of experience with MST and nanoDSF

Protein, DNA, RNA targets analyzed

State-of-the-art Biophysics

Our state-of-the-art portfolio of biophysical technologies enables us to provide you with a complete and comprehensive picture of your specific question: From affinity and stability to kinetics and thermodynamics.

K_D | EC₅₀ | T_m | ΔT_m | T_agg | ΔT_agg | k_on | k_off | n | ΔH | ΔG | ΔS

MST

Steady-state affinity
Ligand binding
Screening
Proteins, DNA, RNA
Bioliquids

nanoDSF

Protein stability
Protein unfolding
Protein aggregation
Ligand binding
Screening
Bioliquids

BLI

Kinetics
Ligand binding
Antibody development
Off-rate ranking
Bioliquids

ITC

Thermodynamics
Stoichiometry
Ligand binding

Clients & Partners

We are impressed with the rapid turnaround time and excellent service, as well the high quality data generated at 2bind.

Brian Hamman, Director of Biophysics Arvinas, Inc.

The [2bind] assay development was well-planned, careful and methodical. Progress reports were frequent, very clear and meticulously prepared. Their science and professionalism are impeccable – working with 2bind is like having expert biophysicists in the lab next door!

Chris Lepre, PhD, Biochemistry, Biophysics and Structural Biology Relay Therapeutics, Inc.

The MST experts at 2bind were successfull in setting up various binding assays, stoichiometry assays, and competition assays and helped us to drive our science. We are very satisfied with the low sample consumption and the fast turnaround time.

Mads Nøregaard-Madsen, Chief Innovation & Information Officer Nuevolution

During several years we have had excellent experience working with 2bind. They have always provided us with the highest-quality services. Quick responsiveness of 2bind’s team has helped us to accelerate projects.
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Dmitry Shishov Gero

We have enjoyed the quality of service of 2bind coupled to a great flexibility. 2bind’s technology allowed us to quickly assess target validation with dozens of proteins and helped us advance quickly on the subject.
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Philippe Verwaerde, President and CSO AlzProtect

We use nanoDSF analyses performed by the experienced team of 2bind in order to gain insights into specific protein parameters. Beside the fast realization and the low sample consumption, we are impressed by the great consistency of both methods.

Martin Griessl, CEO Lysando

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We have been using NanoTemper devices for over eight years and have established a close and very productive relationship together. 2bind has the highest density of NanoTemper devices in one lab world-wide.

Assay.Works is our go-to partner for all biochemical and cell-based assay development and screening requirements. We partner also in the area of ligand compound and bioactive tool compound libraries.