2bind Technologies

2bind’s Powerful Network of Biophysics Technologies Driven by Smart Processes

Need an expert for biophysics technologies?

Trust our expert scientists to choose the right biophysics technologies and methods for the job. Reach your research goals, meet timelines, ensure result quality and benefit from our ingenuity.

You are a technology expert yourself?

Utilize our scalable, versatile collection of biophysics technologies, efficient supporting processes and choose exactly what you need. Meet timelines, scale up developments, and create research bandwidth.

K_D | k_on | k_off | Avidity | T_m | ΔT_m | T_on | T_on-turb | E_A | EC₅₀ | IC₅₀ | r_h | PDI | T_size | T_scattering | k_D | D₀ | B22 | n | ΔH | ΔG | ΔS | t_1/2 | c |

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GCI

Revolutionize Your Screening Workflow with GCI: Fast, Accurate, Label-Free Kinetics and Affinities

Application Areas

Small Molecule Drug Discovery
Fragment-based Drug Discovery
Covalent Drug Discovery
PROTACs and molecular Glues
RNA-targeted Drug Discovery
Antibody Lead Selection
Characterization of bi-specific antibodies
Biologics and Vaccines

Parameters

k_on (k_a)
k_off (k_d)
K_D
Δ_H

Creoptix/Malvern Panalytics Certified Service Provider

BLI

Your Key to Precise Biomolecular Interaction Analysis

Application Areas

PROTACs and molecular Glues
RNA-targeted Drug Discovery
Antibody Lead Selection
Antibody Developability and Formulation
Characterization of bi-specific antibodies
Biologics and Vaccines
Aptamer Discovery

Parameters

k_on (k_a)
k_off (k_d)
K_D
Δ_H
c
Epitope specificity

TRIC/MST

Gain decisive insights for drug discovery and biomolecular characterization with 2bind’s industry-leading TRIC/MST services.

Application Areas

Small Molecule Drug Discovery
Fragment-based Drug Discovery
Covalent Drug Discovery
PROTACs and molecular Glues
RNA-targeted Drug Discovery
Aptamer Discovery

Parameters

K_D
Δ_H
Ligand scouting
Competition Assays
Complex Inhibition Assays
Stoichiometry Assays

Nanotemper Certified Service Provider

Spectral Shift

Unlock the secrets of molecular interactions with the power of the Spectral Shift technology and 2bind’s industry-leading expertise.

Application Areas

Small Molecule Drug Discovery
Fragment-based Drug Discovery
Covalent Drug Discovery
PROTACs and molecular Glues
RNA-targeted Drug Discovery
Aptamer Discovery

Parameters

K_D
Δ_H
Ligand scouting
Competition Assays
Complex Inhibition Assays
Stoichiometry Assays

Nanotemper Certified Service Provider

nanoDSF

Unveil stability and folding of proteins or efficiently screen for ligand binding with the power of nanoDSF and 2bind’s industry-leading expertise.

Application Areas

Small Molecule Drug Discovery
Fragment-based Drug Discovery
Covalent Drug Discovery
PROTACs and molecular Glues
Antibody Developability and Formulation
Characterization of bi-specific antibodies
Biologics and Vaccines

Parameters

T_m
T_on
E_A
T_on-turbidity
T_m-diff
EC₅₀

Nanotemper Certified Service Provider

DLS

Accelerate Your Biologics Research with Dynamic Light Scattering (DLS) and 2bind’s industry-leading expertise.

Application Areas

Small Molecule Drug Discovery
Covalent Drug Discovery
PROTACs and molecular Glues
RNA-targeted Drug Discovery
Antibody Developability and Formulation
Characterization of bi-specific antibodies
Biologics and Vaccines

Parameters

r_H
PDI
T_size
T_scattering
k_D
D₀
B22
HMS content

Nanotemper & DLS by WYATT Technologies Certified Service Provider

ITC

Unravel molecular interaction details with the power of ITC and 2bind’s industry-leading expertise.

Application Areas

Small Molecule Drug Discovery
Covalent Drug Discovery
PROTACs and molecular Glues
RNA-targeted Drug Discovery
Aptamer Discovery

Parameters

K_D
n
Δ_H
Δ_G
Δ_S

switchSENSE

Reveal conformational changes induced by analyte binding or buffer conditions with switchSENSE analysis.

Application Areas

Small Molecule Drug Discovery

Parameters

Conformational change
Relative sizing experiments
EC₅₀/IC₅₀

Dynamics Biosensors Certified Service Provider

kinFRET

Decipher Complex Biomolecular Interactions with 2bind’s heliX® kinFRET Expertise.

Application Areas

PROTACs and molecular Glues
Characterization of bi-specific antibodies

Parameters

k_on (k_a)
k_off (k_d)
K_D
EC₅₀/IC₅₀

Dynamics Biosensors Certified Service Provider

FPS

Elevate Your Research with 2bind’s heliX® FPS Expertise.

Application Areas

PROTACs and molecular Glues
Characterization of bi-specific antibodies
Aptamer Discovery

Parameters

k_on (k_a)
k_off (k_d)
K_D
Avidity
Δ_H
EC₅₀/IC₅₀

Dynamics Biosensors Certified Service Provider

SEC-MALS – HIC – IEX

Improve your biologics and antibody development with 2bind’s expertise in multi-parameter HPLC Analytics.

Application Areas

Size-Exclusion Chromatography
Hydrophobic-Interaction Chromatography
Ion-Exchange Chromatography

Parameters

Molecular weight
Covalent and colloidal integrity
Stoichiometry of protein complexes
Purity
Hydrophobicity
Charge state and charge variants
Post-translational modification

SEC-MALS Certified Service Provider

RT-IC

Revolutionize Cell-Based Research with 2bind’s heliXcyto® and RT-IC Expertise

Application Areas

Antibody Lead Selection
Antibody and Developability and Formulation
Characterization of bi-specific antibodies

Parameters

k_on (k_a)
k_off (k_d)
K_D
Avidity
EC₅₀/IC₅₀
Relative amplitudes for bi-phasic interactions
Half-life (t1/2) on the cell surface
Competition experiments

Dynamics Biosensors Certified Service Provider

Flow Cytometry

Advanced Flow Cytometry Solutions for Targeted Drug Discovery

Application Areas

Antibody Lead Selection
Antibody and Developability and Formulation
Characterization of bi-specific antibodies
Biologics and Vaccines

Parameters

MFI
Identification of subpopulations
Complex functional assays
Binding EC₅₀

Stopped Flow

Unlock the Secrets of Fast Molecular Interactions

Application Areas

Small Molecule Drug Discovery
Fragment-based Drug Discovery
Covalent Drug Discovery
PROTACs and molecular Glues
RNA-targeted Drug Discovery

Parameters

Microscopic and macroscopic rate constants (k_on, k_off)
Dynamics of conformational changes
Reaction kinetics
K_D and EC50