Antibodies in their numerous forms are the backbone of modern therapeutics that target cancer, autoimmune, and infectious diseases. Moreover, highly-specialized antibodies and their derivatives are the basis of precise diagnostic tools.
Antibody developers benefit from our broad range of biophysical services. Interactions between antibodies and antigens can be analyzed with a variety of biophysical methods (see below). Antibody stability and aggregation is easily acceesible via our tailor-made nanoDSF assays.
Optimization of antibody buffer and storage conditions as well as development of pre-formulations is now easier than ever with the 2bind FORMOscreen®: A collection of 96 ready-to-use buffer conditions from FDA- and EMA-approved therapeutic antibodies. With the FORMOscreen® you can use the same antibody storage buffers as the experts do. Get more information here!
Characterizing Antibody Target Interactions
Precise information about antibody-target interactions is key for developing therapeutic and diagnostic antibodies. Our versatile toolbox of biophysical methods (MST, BLI, and ITC) is tailored towards maximum flexibility in investigating several aspects of antibody target interactions.
If you want to read more on the biophysical and technical background of the applied methods, please have a look at our technology section. For examples of antibody target interactions, we would like to refer you to our application notes. You can also use the contact form below to ask us anything about the services outlined below. We will get back to you shortly with a solution made specifically for your request!
Steady-state Binding Assay - MST, BLI, ITC
Dynamic Kinetic Assay - BLI
Thermodynamics Assay - ITC
Assays in Biological Liquids - MST
Epitope Binning - BLI
Discriminate between different interaction epitopes on the same antigen using in-tandem, competition, or pre-mix kinetic assays.
Antibody Quantification - BLI
Determine the expression level of antibody clones directly in cell culture supernatants with high precision and low detection limits.
High-throughput ligand screening - MST
Analyze your antibody in high-throughput screening assays for binding to up to 1000s of possible antigens, e.g. peptide epitopes.
Studying Antibody Stability and Antibody Aggregation
Knowing the stability of an antibody is essential in many cases. Our precise, versatile, fast, and cost-efficient nanoDSF assays allows for the determination of antibody stability in a wide range of applications outlined below.
For specific examples where antibody stability has been an important part of antibody development, take a look at our application notes. You can also use the contact form below to ask us anything about our antibody services. We will get back to you shortly with a solution made specifically for your request!
Find the optimal buffer or buffer additives for your antibody in a pre-formulation phase buffer screening. We can work with specifically designed buffer for your case or with our specialized pre-formulation buffer plate: The FORMOscreen®.
Long-term Storage Optimization
Identify the optimal conditions for storing your antibody over a defined period of time. Long-term storage assays can be added as a subsequent module after buffer screening assays. Use with our FORMOscreen®.
Forced Degradation Assays
Compare your biosimilars to the originator. Comparison assays are modular and can combine buffer screenings, long-term storage tests, as well as forced degradation analysis.