Our Services for Aptamer Characterization
Aptamers are state-of-the-art macromolecular drugs with clinical applications, as well as synthetic binding and sensory tools for industrial diagnostics and basic research. Aptamer developers benefit from our extensive experience in aptamer characterization and our derived broad portfolio of suitable biophysical assays.
If you are interested in specific example applications, please have a look at our application notes. You can also use the contact form below to ask us anything about the services outlined below. We will get back to you shortly with a solution made specifically for your request!
Steady-state Aptamer Binding Assay - MST, BLI, ITC
Determine the steady-state affinity (KD) of your aptamer to its natural target or to any other target: ranging from ions and small molecules, over peptides, DNA, and RNA, to proteins or synthetic particles.
Kinetic Aptamer Binding Assay - BLI
Study on- and off-rates (kon, koff) of interactions between aptamers and target molecules. Compare different aptamers with respect to their kinetic behavior using our BLI-platform.
Thermodynamic Aptamer Binding Assay - ITC
Characterize aptamer target interactions with respect to their thermodynamics parameters including enthalpy (ΔH), free enthalpy of binding (ΔG), entropy (ΔS), and stoichiometry using ITC.
Assays in Biological Liquids - MST
Determine aptamer-target interactions in relevant biological liquids such as serum, plasma, cell lysate, urine, mucose, or environmental matrices. Exclude unwanted side-interactions in these biological matrices.
Sandwich Assays - MST, BLI
Benefit from our fast and robust aptamer assays for selecting a pair of aptamers against the same target for the development of aptamer-based sandwich diagnostic tools.
Competition Assays - MST, BLI
Determine the ability of your aptamer to disrupt the complex of a target molecule and its natural ligand. Alternatively, test the influence of your aptamer on interactions between a target and its natural ligand.