Buffer screening applications
Buffer screening made easy for your antibodies and proteins. Use the 96 individual, specific, and pre-made buffer conditions from approved Formulations of Developed Antibodies.
All buffers were designed by antibody formulation experts and have already proven to be beneficial for stability and storage of therapeutic antibodies. Each buffer has been approved by FDA or EMA for use in antibody formulations.
Use the FDA-plate® for buffer screening, analysis of protein and antibody stability, buffer optimization, and (pre-) formulation development. Or use the plate to determine important parameters for regulatory approval of your antibodies like colloidal stability, thermal stability, freeze-thaw resistance, chemical stability, or long-term and forced degradation behavior.
Identify optimal conditions for antibody and protein stability by simple and quick buffer screening. Thermal and chemical stability, long-term storage, forced-degradation, and (pre-)formulation.
Apply the buffer screening plate quickly and easily to your methods of choice (e.g. DSF, nanoDSF, DSC, DLS, LC-MS, SEC-HPLC, ELISA).
The buffer screening plate is the optimal starting point for pre-formulation development and buffer optimization of antibodies and other proteins.
• 96 conditions from FDA- and EMA-approved formulations of therapeutic antibodies
• Ready-to-use 5x buffer screening stock solutions (0.2 mL)
• Wide range of different buffer compositions:
pH: 4.6 – 8.0 (acetate, citrate, glycine, histidine, phosphate)
Salts: 3 – 200 mM (potassium chloride, sodium chloride)
Amino acids: 1 – 300 mM (glycine, glutamate, methionine, proline)
Sugars: 12 – 300 mM (maltose, mannitol, sorbitol, sucrose, trehalose)
Detergents: 0 – 1.6% (polysorbate 20, polysorbate 80)
No need to prepare buffers. Just dilute your sample of choice into the pre-made buffers and you are ready to go for buffer screening.
No need to buy small quantities of expensive buffer substances. Cut analysis costs by saving hands-on-time in the lab.
All buffers are made to highest quality standards and are tested with reference antibodies. Each buffer is also available as a re-fill stock for additional buffer screening.
Explore the power of the 2bind “Formulation of Developed Antibodies” plate for buffer screening, antibody pre-formulation development, and many more applications below. For a list of all application notes visit our AppNote database. For an overview of all services we offer, check the services for antibodies or the services for protein analysis.
Read more on how to use the 2bind “Formulations of Developed Antibodies” buffer screening plate for antibody buffer and stability optimization as well as quickly developing pre-formulation conditions.
Full 96-buffer plate96 buffers, 0.2 mL each (5x stock)
Individual buffers1 buffer, 25 mL (5x stock)
Measurement ServiceAanalysis of full 96-buffer conditions with your protein(s) of choice. Stability, unfolding, aggregation, colloidal parameters, size distribution, polydispersity
Let us do the work for you
2bind is one of the world’s leading service providers for biophysical analyses in drug discovery, antibody development, aptamer research, and protein biophysics.
From over 8 years of experience in these fields, we know what really matters: Quality, speed, and affordable costs.
Therefore, we also offer to analyze your samples of choice for you in a high-throughput buffer screening setup:
- Minimal sample consumption (100-300 µg antibody for full 96-buffer analysis).
- Investigation of antibody/protein stability, unfolding, refolding, aggregation, colloidal parameters, size distribution, etc.
- Including detailed data analysis and reports.
- All that for very affordable costs and with quick timelines.
Request your plate or 2bind service
Fill out the form to the right and we will provide you with a quotation shortly, typically within only a few hours.
Just select an option or whether you prefer a 2bind-antibody or protein analysis service using the “Formulations of Developed Antibody” buffer screening plate and a state-of-the-art nanoDSF assay.