Our Services

We are the experts in biophysics. Whether you are looking for scientific excellence, research, transparency, and effectiveness, or scalable processes, efficiency, and outsourcing capacities: We are your personal biophysics lab.

Our Technologies

A powerful network of technologies driven by smart processes.

2bind is the prime choice for biotechs and pharma companies around the world.

We are a trusted partner for challenging assay development, large-scale biophysics screening campaigns and deep dives into science.

Our Services

Tailor-made services for hit identification, hit confirmation, hit characterization, and support of hit-to-lead programs. We cover target validation, assay development, liquid handling, screening, SAR and MedChem support, critical data processing and analysis, as well as comprehensive and clear reporting of results.

Also check small molecules for solubility and precipitation parameters to assist in ligand selection and drive of lead molecule generation.

Fit to the needs of fragment-based drug discovery, we provide specialized fragment libraries as well as the right tools for screening them. In addition, we cover the required experimental parts for fragment growth, MedChem cycles, SAR by catalogue and fragment-to-lead programs.

Specialized binding and screening assays and services for identification, characterization, and optimization of covalent drugs.

Also check covalent compounds for solubility and precipitation parameters to assist in ligand selection and drive of lead molecule generation.

We understand that these special chemical molecules require specialized assay formats. We provide not only binary binding analysis of PROTACs and molecular glues to their two targets, but also direct measurement of their intended function, bringing together two normally not associated targets. We can do this by direct analysis of ternary complex formation with full kinetic, affinity, and avidity information.

Also check molecules for solubility and precipitation parameters to assist in ligand selection and drive of lead molecule generation.

Fit to the needs of RNAs as drug targets, we provide specialized RNA-binding assay formats, as well as the relevant RNA-binder compound library. Understanding how to work with RNAs, our screening assays are set up to work with nanomolar amounts of RNA.

We cover binding kinetics, off-rate ranking, epitope-binning, test of avidity effects, as well as binding analysis of antibodies on live cells. The latter is especially useful for challenging targets that cannot be purified and have to be tested in their cellular context.

We ensure the developability of your antibodies through a battery of advanced techniques, including nanoDSF, DLS, SEC-MALS, HIC, and IEX. This comprehensive approach provides invaluable insights into key parameters such as thermal and colloidal stability, self-interaction, hydrophobicity, and chemical stability. Furthermore, our formulation studies, driven by statistically sound design of experiments (DoE), proactively address potential risk factors, paving the way for successful development.

2bind’s comprehensive portfolio delivers in-depth characterization of your antibodies and bispecifics, providing critical insights into binding interactions with target proteins and cells, along with meticulous assessments of conformational, colloidal, and chemical stability. We tailor these studies to meet your specific needs, whether you require a comprehensive analysis or targeted answers to particular scientific questions.

Characterize and optimize! Set the basis for successful development campaigns with detailed target characterization in terms of stability, purity, homogeneity, hydrophobicity, charge state, and more. Optimize these parameters with high-throughput capable, statistically driven (DoE) assays.

Whether aptamers should serve as antibody alternatives or molecular sensors, we provide the right tools and assays for binding characterization to all kinds of targets: Ions, hormones, drugs, peptides, proteins, DNA, RNA, virus-like particles, or even live cells.
Our Technologies

Technologies put together by experts.

Besides gold-standards like ITC, BLI, TRIC, or Wyatt DLS, we continuously integrate cutting-edge tools like GCI (Wave), RT-IC (heliXcyto), or Spectral Shift. Developer certifications ensure that we provide these technologies to the highest possible quality standards.

About us

Our Vision is to make biophysics accessible to everyone, accelerating the development of medicines and tools that improve lives and create a happier, healthier, and smarter world.

Our commitment goes beyond science. We have set ourselves unconditional compliance,quality, ethical, social, and sustainability guidelines.
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Customers

From Biotech, Pharma, and Academia

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Projects
Successfully completed since 2017
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Different Biomolecules
Tested as drug targets or biologics
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Different Antibodies
Tested for lead selection or developability

As scientists we understand that successful research requires a clear but also flexible approach. Our quotations, project and reports reflect this need with a fine-grained milestone architecture with multiple stop criteria and exit options.

The milestone-based project architecture also involves detailed pricing for each milestone to provide optimal transparency and consistency.
You don’t have to wait long before we get going. Normally, project lead-times are roughly 1-2 days up to two weeks maximum. During a project, we regularly provide you with progress updates and intermediate results either via e-mail or in digital meetings.
We are not a black box. Our goal is to be no different than working with your lab next door. We are happy to take as many meetings and discussion before project start or after conclusion of a project as you feel are necessary. We also do not hold back with our expertise and provide scientific input beyond just describing the results.
All our senior scientists who manage the projects are scientists like you. They understand that you have to meet timelines and project milestones and therefore they bring their best to be highly responsive and available for communication at all times.
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