In the optimization and pre-formulation phase, it is paramount to find influencing factors. With sheer endless combinations of factors that influence each other getting data to make informed decisions can be a challenge. From antibodies, peptides or RNAs to proteins, biologics, and vaccines, our specialized technologies offer essential insights to understand your sample. Whether preparing for GMP studies, optimizing downstream processes (DSP), or assessing stability under stress conditions, our expertise empowers you to make the right choices at every stage of development.
What 2bind can do for you
Team composition depending on the molecule type of interest
Data analysis, literature research, structural analysis, etc.
Scope and deliverable definition
Technology, process, and assay cascade definition
Material access and sourcing
Reagent and target molecule qualification
Technical assay parameter establishment
Instrument and assay qualification
First agreement on potential stress testings and optimization factors
Design of Experiment (DoE) approach to find relevant factors that influence the sample of interest
Assay format and stress-testing according to communicated requirements
nanoDSF for conformational stability
DLS for colloidal stability
SEC MALS for size determination, colloidal stability
HIC for hydrophobic profiling
IEX for charge profiling
Computational expert statistical analysis
Use the 2bind FORMOscreen® Formulation Screen for a more crude approach
Use the 2bind KOMBOscreen® Formulation Screen for a more targeted approach
Response Surface Methodology (RSM) approach to find quadratic relations between chosen factors
Assay format and stress-testing according to requirements
nanoDSF for conformational stability
DLS for colloidal stability
SEC MALS for size determination, colloidal stability
HIC for hydrophobic profiling
IEX for charge profiling
Computational expert statistical analysis
Analytical verification of computer-supported analysis
Referencing and Comparative analysis of conditions
Assay format and stress-testing according to requirements
DLS for colloidal stability
SEC MALS for size determination, colloidal stability
HIC for hydrophobic profiling
IEX for charge profiling
What 2bind delivers
