Work with the fastest CRO in the world and unlock the potential of your small molecule drug discovery.
Integrated Services for Preclinical Small Molecule Drug Discovery.
At 2bind, we support your early stage small molecule drug discovery from target to lead.
Our integrated service portfolio covers protein purification, hit identification, hit validation, and hit-to-lead optimization – all powered by our partner network and our scalable assay platform. Designed for rapid turnaround and high data quality, our services enable fast, confident decision-making and seamless project progression.
Our Integrated Small Molecule Drug Discovery Services
Protein Target Purification
- Construct design consulting
- Production consulting
- Quality controlling
Hit Identification
- Assay establishment
- Assay upscaling
- Screening
Hit Validation
- Orthogonal assay suite
- Validation of hits
Hit-to-Lead
- Rapid assay turnover
- Support for MedChem and SAR efforts
Lead Optimization
- In-depth characterization
- CMC support
- IND filing support
From Target to Lead with Speed and Precision
At 2bind, we empower biotech and pharma innovators with end-to-end support across the early stages of small molecule drug discovery.
Our approach combines deep scientific expertise, scalable assays, and a strong commitment to rapid turnaround – making us a reliable partner from target assessment through to lead optimization.
That’s why we’ve built our services around speed, precision, and transparency. Our fully digitalized workflows ensure seamless communication, traceability, and rapid data delivery – empowering you to make confident decisions without delay.
Small Molecule Drug Discovery
Protein Target Purification
Our discovery process begins with the delivery of high-quality proteins.
Depending on your needs, we either consult establishing a tailored purification strategy or offer access to a catalogue of validated purified proteins. All proteins undergo rigorous quality controlling, ensuring they meet the necessary standards for our downstream applications.
Small Molecule Drug Discovery
Hit Identification
We support your screening efforts with custom assay development, scalable assay formats, and a robust screening infrastructure.
From assay establishment and optimization to upscaling and high-throughput screening, our hit identification phase is designed to be both flexible and fast – delivering reliable data at high-speed that drives confident decision-making.
Small Molecule Drug Discovery
Hit Validation
Complementing the screening campaign, our team rapidly deploys orthogonal assays to confirm and validate promising hits.
By integrating different methods, we ensure that potential binders are not only reproducible but also specific and functionally relevant. This step helps eliminate false positives early and increases the confidence in your hit list.
Small Molecule Drug Discovery
Hit-to-Lead
Once hits are validated, we accelerate the transition to lead candidates by committing to fast, iterative binding assessments.
This allows seamless integration with your Medicinal Chemistry workflows and supports efficient Structure–Activity Relationship (SAR) studies. Our platform enables frequent data delivery to help guide modifications and molecule evolution and focus your lead optimization strategy.
Small Molecule Drug Discovery
Lead Optimization
During small molecule lead optimization, we support medicinal chemistry teams with high-quality, decision-enabling data that goes beyond simple potency measurements. Through direct binding analyses, target-level functional assays, and cell-based functional and target engagement studies, we help translate chemical modifications into meaningful biological improvements.
Complemented by physicochemical profiling and written feasibility assessments, our approach reduces uncertainty, shortens optimization cycles, and supports confident progression toward robust drug candidates.
"Their science and professionalism are impeccable – working with 2bind is like having experts in the lab next door."
Chris Lepre, PhD, Relay Therapeutics
In-Depth Target and Lead Characterization
1
Physicochemical Assessment
- Small molecule aggregation and solubility
- Target aggregator assays for binding analysis
2
Target Quality / Stability Assessment
- Conformational and colloidal stability
- Size and Oligomerization
- Purity, homogeneity, monodispersity
3
In-Depth Binding Characterization
- Affinity Determination
- Kinetics Determination
- Covalent Binding Assessment
- Stoichiometry Assay
- Interaction Thermodynamics
- Thermal Shift Assay
To support confident progression, we offer in-depth hit and lead characterization studies, including physicochemical assessments of small molecules, comprehensive binding characterization, and target protein quality and stability profiling. These insights provide a robust data package to de-risk development decisions and accelerate your path to clinical success
Broad Expertise Across Chemical Modalities and Target Classes
Our small molecule services are designed to support all chemical modalities – from fragments to complex small molecules and covalent modalities.
Our team of experts combined with our assay platform brings extensive experience and value across a range of target classes, including enzymes, receptors, protein–protein interactions, RNAs, and more.
Whether your molecule is classical or intrinsically disordered, we provide the processes and capabilities to move your project forward with confidence.
Protein Target Purification
- Compounds
- Fragments
- Covalent small molecules
- PROTACs, Glues, RIPTACs, other multispecifics
- Peptides
- Macrocycles
Target Classes
- Globular Proteins
- Intrinsically Disordered (IDPs, IDRs)
- Membrane Proteins
- Multiprotein complexes
- RNAs
- Transkription Factors
- DNA and Aptamers
Disease Areas
- Cancer
- Autoimmune diseases
- Infectious diseases
- Neurological disorders
- Metabolic diseases
- Cardiovascular diseases
Get in Touch!
"I’ve always been extremely satisfied with the service provided by 2bind. Communication has consistently been straightforward and uncomplicated, making collaborations very pleasant and efficient. The results and data we received were of high quality and fully trustworthy, which gave us great confidence in our decision-making. I happily recommend 2bind to anyone looking for reliable and professional support in their projects."
Johanna Gellert, PhD, Pentixapharm
Get In Touch
Planning a research project or interested in our analytical services? Get in touch with our team to discuss your requirements.
- +49 941 2000 0890
- info@2bind.com
- Im Gewerbepark D19a, 93059 Regensburg, Germany