Work with the fastest CRO in the world and unlock the potential of your small molecule drug discovery
Stand-Alone Services for therapeutic Small Molecules.
Our stand-alone offering includes access to quality proteins, high-throughput interaction screening, direct binding assessments, functional cell-based or enzymatic assays, and physicochemical and stability profiling. These services are backed by our scalable assays and rapid turnaround times, ensuring reliable and actionable data.
With deep experience across diverse chemical modalities and target classes, our scientific team delivers fit-for-purpose solutions that integrate seamlessly into your project – whether you’re at hit discovery, optimization, or any point in between.
Our Stand-Alone Services for your Small Molecule Drug Discovery
Small scale protein target purification
Small scale protein target purification
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Construct design consulting or access to catalogue proteins
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Production consulting
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Purification monitoring
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Quality controlling
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Direct Binding Assays
Direct Binding Assays
Affinity Determination
Spectral Shift, TRIC, ITC, FP Assay, Flow Cytometry
Kinetics Determination
GCI (SPR-like)
Covalent Binding Assessment
Spectral Shift, GCI
Stoichiometry Determination
ITC, Spectral Shift, TRIC, GCI
Interaction Thermodynamics
ITC
Thermal Shift Assay
nanoDSF
Screening of small sets or libraries
GCI, Spectral Shift, nanoDSF, FP Assay
Functional assays
Functional assays
Cell viability and toxicity (cell death)
BSL1, BSL2, state-of-the-art kits
Cellular Signaling & Cellular Response
BSL1, BSL2, state-of-the-art kits, direct or second messenger (e.g. GPCR)
Target engagement
BSL1, BSL2, state-of-the-art kits
Enzyme Kinetics
State-of-the-art kits, Kinases, Phosphatases, etc.
Physicochemical and Stability Assessments
Physicochemical and Stability Assessments
Small Molecule Aggregation and Solubility
DLS
Target conformational and colloidal stability
nanoDSF, DLS
Target size and oligomerization
SEC-MALS, HPLC
Target aggregator assays for binding analysis
nanoDSF, DLS, SEC-MALS
Target and lead stability optimization approach
nanoDSF, DLS, SEC-MALS, binding assay
Other services
Other services
Ternary complex assay formats
GCI, Spectral Shift, TRIC, BLI, nanoDSF, DLS
Small molecule library spotting
Compound library management
Small molecule cherry picking and shipping
Compound library management
Platforms and standing assays
Platforms and standing assays
Target feasibility platform
Explore whether your target construct is suitable for a relevant binding assay
Standing binding assays
Reach out to us if you want to know if we have a standing assay for your target construct
Direct binding data generation for AI-based drug discovery
Artificial intelligence is transforming drug discovery by generating vast numbers of virtual compounds and in silico predictions. At 2bind, we close the gap between digital design and experimental reality with direct binding screening and validation services tailored for AI-driven approaches.
Whether you need to screen a large in silico library, test a few hundred compounds, or validate selected virtual hits, our scalable biophysical assay platform delivers rapid, high-quality data on binding affinity, kinetics, and specificity. Nothing provides deeper insights than biophysics—and with our data, your algorithms don’t just get validated, they get smarter. By feeding high-resolution binding data back into your AI models, we help refine and train algorithms to improve future predictions.
We also support validation runs for virtually designed small molecules, ensuring that promising candidates are confirmed early and that AI-generated hypotheses are tested against real-world molecular interactions.
With 2bind as your partner, you gain the reliability, speed, and scalability needed to integrate AI-based discovery seamlessly into your drug development pipeline.
Get in Touch!
"I’ve always been extremely satisfied with the service provided by 2bind. Communication has consistently been straightforward and uncomplicated, making collaborations very pleasant and efficient. The results and data we received were of high quality and fully trustworthy, which gave us great confidence in our decision-making. I happily recommend 2bind to anyone looking for reliable and professional support in their projects."
Johanna Gellert, PhD, Pentixapharm
We commit to rapid timelines
Our Target Feasibility Platform
In early-stage drug discovery, speed is critical. Our Target Feasibility Platform is designed to quickly determine whether a target construct is suitable for a relevant biophysical binding assay. By combining streamlined workflows with our specialized expertise, we deliver reliable results within just 5 days – allowing you to move forward with confidence and without delay.
This rapid turnaround empowers project teams to make informed decisions early, saving valuable time and resources, and ensuring that only the most suitable targets enter the next stage of development. We have built this platform with the specific goal of accelerating the discovery process – because in drug discovery, every day counts.
So if you are working with platforms that produce multiple targets, target constructs, make sure to contact us for our target feasibility platform.
Even for single target companies, we apply our target feasibility platform to quickly identify applicability.
Kinetics Determination Assay
Affinity Determination Assay
Qualitative Binding Assay
Thermodynamic Binding Assay
Our Suite of Standing, Scalable Binding Assays – Ready to Accelerate Your Discovery Phase
Drawing on years of experience in drug discovery, we have developed a suite of pre-developed, high-quality binding assays for a wide range of protein targets. These assays are ready to deploy after a feasibility check, enabling rapid screening of small molecules without the need for assay establishment.
Each standing assay includes reliable production and sourcing of high-quality molecules, ensuring that your screening campaign starts on solid ground. Our assays are fully scalable—from small exploratory screens to high-throughput campaigns—providing flexibility to match your project needs and timelines. By combining proven assay designs with robust infrastructure and quality control, we deliver reproducible, reliable results that accelerate your path to hit identification.
Broad Expertise Across Chemical Modalities and Target Classes
Our small molecule services are designed to support all chemical modalities — from fragments to complex small molecules and covalent modalities.
Our team of experts combined with our biophysical platform brings extensive experience and value across a range of target classes, including enzymes, receptors, protein–protein interactions, or RNAs. Whether your molecule is classical or intrinsically disordered, we provide the processes and capabilities to move your project forward with confidence.
Chemical Modalities
- Compounds
- Fragments
- Covalent small molecules
- PROTACs, Glues, RIPTAcs, other multispecifics
- Peptides
- Macrocycles
Target Classes
- Globular Proteins
- Intrinsically Disordered (IDPs, IDRs)
- Membrane Proteins
- RNAs
- Transkription Factors
- DNA and Aptamers
Get in Touch!
"I’ve always been extremely satisfied with the service provided by 2bind. Communication has consistently been straightforward and uncomplicated, making collaborations very pleasant and efficient. The results and data we received were of high quality and fully trustworthy, which gave us great confidence in our decision-making. I happily recommend 2bind to anyone looking for reliable and professional support in their projects."
Johanna Gellert, PhD, Pentixapharm
Get In Touch
Planning a research project or interested in our analytical services? Get in touch with our team to discuss your requirements.
- +49 941 2000 0890
- info@2bind.com
- Im Gewerbepark D19a, 93059 Regensburg, Germany