Our Products

FORMOscreen®

Description

The FORMOscreen® allows for rapid characterization of your antibody of choice in 96 pre-made buffer conditions, derived from the formulations of therapeutic antibodies approved by the FDA (Food and Drug Administration, USA) and the EMA (European Medicines Agency, EU). The substance combinations have already shown to have positive effects on antibody formulation and stability and thus provide optimal starting points for developing pre-formulations for therapeutic and diagnostic antibody candidates.

Applications

• Ideal for antibody stability screening and unfolding analysis
• Allows for rapid characterization of buffer influence on chemical, thermal, colloidal, and conformational stability, long-term storage stability, forced-degradation resistance, as well as biochemical activity and antigen-binding
• Enables quick-and-easy buffer optimization and pre-formulation
• Use with your biophysical or biochemical read-out of choice (e.g. DSF, nanoDSF, DSC, DLS, LC-MS, SEC-HPLC, ELISA, etc.)
• Can just as well be used for stability analysis and buffer optimization of any kind of protein
  
  

Content

Deep-well plate with 96 FDA- and EMA-approved formulations of therapeutic antibodies provided as ready-to-use 5x stock solutions (230 μl each) with a wide range of different buffer compositions (1x at 25 °C):

• pH: 4.6 – 8.0 (acetate, citrate, glycine, histidine, phosphate)
• Salts: 3 – 200 mM (potassium chloride, sodium chloride)
• Amino acids: 1 – 300 mM (glycine, glutamate, methionine, proline)
• Sugars: 12 – 300 mM (maltose, mannitol, sorbitol, sucrose, trehalose)
• Detergents: 0 – 1.6% (polysorbate 20, polysorbate 80)

The FORMOscreen® buffers are formulated using high-purity chemicals and ultrapure water (>18.0 MΩ) and are sterile-filtered using 0.22 μm filters. No preservatives are added. Prepared at room temperature. Please note that the storage buffer of the target antibody or protein may affect the final pH and/or buffer composition of the buffers. It is thus recommended to work with highly-concentration target antibody or protein stock solutions in order to generate a maximum dilution effect when diluting the target antibody or protein into the buffers.