2bind Services

2bind: Advancing Research and Development Through Specialized Biophysics Services

Need an expert in biophysics?

Trust our expert scientists and their input, our smart and effective services, and our technology network. Reach your research goals, meet timelines, ensure result quality and benefit from our ingenuity.

You are an expert yourself?

Utilize our scalable, streamlined, and efficient processes and platforms. Meet timelines, scale up developments, and create research bandwidth.

Small Molecule Drug Discovery

Customized solutions crafted for hit identification, confirmation, characterization, and assistance in hit-to-lead programs. Our expertise spans target validation, assay development, liquid handling, screening, SAR, and MedChem support, along with meticulous data processing and analysis. We also provide comprehensive and transparent result reporting to ensure your project’s success.

We have handled countless small molecules in our assays. We are well-versed in the intricacies of this process, therefore employing specialized equipment and procedures such as contactless, fully-automated, ultra-sound spotting with the LabCyte Echo platform, proprietary high-throughput analysis tools, and tailored quality controls (e.g small molecule solubility, precipitation testing). 

Fragment-based Drug Discovery

Tailored to meet the demands of fragment-based drug discovery, we offer specialized fragment libraries along with the appropriate screening tools. Furthermore, our services encompass the essential experimental components for fragment growth, MedChem cycles, SAR by catalog, and fragment-to-lead programs.

Fragment-based drug discovery requires a different perspective on binding assays, because of the initially inherent weak binding affinity of fragments and their potential for showing false-positive results. At 2bind, our fragment-screening and binding assays, including MST, Spectral Shift, and GCI, effectively address the requisite lower affinity range (up to mM). Our skilled scientists possess the expertise to navigate and interpret the nuances associated with fragments, ensuring accurate and insightful results.

RNA-targeted Drug Discovery

Tailored to cater to the demands of RNAs as potential drug targets, we offer specialized formats for RNA-binding assays along with a curated library of compounds specifically designed for RNA binding. With a deep understanding of working with RNAs, our screening assays are designed to operate efficiently with nanomolar quantities of RNA.

Understanding the intricacies of RNA folding and secondary/tertiary structures is essential for designing effective RNA-targeted drugs. Therefore, the 2bind RNA binding assays are designed to work with only minimal impact on RNA structure, e.g. completely modification-free and in-solution via calorimetry. 

Biophysics and other Services

Small Molecule Drug Discovery Services

Tools and services for everything from assay development and high-throughput library screening, over hit validation and characterization, to MedChem and lead generation support.

Fragment-based Drug Discovery Services

Assays and services for fragment-library screening, hit validation and characterization. Support of fragment growth and lead generation.

Covalent Drug Discovery Services

Specialized binding assays, screening assays, and services for identification, characterization, and optimization of covalent drugs.

PROTACs and Molecular Glues Services

Specialized binding, screening, and other assays and services for identification, characterization, and optimization of molecular glues and PROTAC drugs.

RNA-targeted Drug Discovery Services

Assays and services for everything from assay development and high-throughput library screening, over hit validation and characterization, to MedChem and lead generation support specifically tailored for RNA targets.

Antibody Lead Selection

Assays and services for screening and evaluating antibody drug leads with respect to binding, kinetics, or interaction with targets on live cells.

Antibody Developability and Pre-Formulation Services

Suite of assays, tools, products, and services for optimizing developability and pre-formulation of antibodies for more successful IND, DSP, and stress resilience.

Characterization of Antibodies and Bispecifics

Specialized assays and services for all kinds of bi- or multi-specific antibodies providing accurate binding dynamics and specificities.

Biologics and Vaccines Services

Suite of assays, tools, products, and services for formulating biologics or protein vaccines. More successful preparation of GMP manufacturing, DSP, or testing stress conditions.

Aptamer Discovery Services

Assays and services for analysis of binding affinity, kinetics, and thermodynamics of aptamers with all kinds of targets, from proteins to small molecules.

This is how we work

Milestone-based projects with clear and attractive pricing structure

As scientists we understand that successful research requires a clear but also flexible approach. Our quotations, project and reports reflect this need with a fine-grained milestone architecture with multiple stop criteria and exit options. This architecture also involves detailed pricing for each milestone to provide optimal transparency and consistency.

Short lead times and regular progress updates

You don’t have to wait long before we get going. Normally, project lead-times are roughly 1-2 days up to two weeks maximum. During a project, we regularly provide you with progress updates and intermediate results either via e-mail or in digital meetings.

Valuable scientific input before, during, and after a project

We are not a black box. Our goal is to be no different than working with your lab next door. We are happy to take as many meetings and discussion before project start or after conclusion of a project as you feel are necessary. We also do not hold back with our expertise and provide scientific input beyond just describing the results.

Responsible, personal contact persons

All our senior scientists who manage the projects are scientists like you. They understand that you have to meet timelines and project milestones and therefore they do their best to be highly responsive and available for communication at all times. 